US 7,576,220 B2
Method of producing 1,2,4-oxadiazole derivatives
Akira Horiuchi, Tokyo (Japan); Ken-ichi Itoh, Saitama (Japan); and Hiroshi Sakamaki, Chiba (Japan)
Assigned to Rikkyo Gakuin, Tokyo (Japan)
Appl. No. 11/662,280
PCT Filed Apr. 06, 2006, PCT No. PCT/JP2006/007351
§ 371(c)(1), (2), (4) Date Mar. 09, 2007,
PCT Pub. No. WO2006/123486, PCT Pub. Date Nov. 23, 2006.
Claims priority of application No. 2005-142692 (JP), filed on May 16, 2005.
Prior Publication US 2008/0086009 A1, Apr. 10, 2008
Int. Cl. C07D 271/12 (2006.01)
U.S. Cl. 548—131 8 Claims
 
1. A method of producing a 1,2,4-oxadiazole derivative represented by formula (1)

OG Complex Work Unit Drawing
(wherein R1 represents a methyl group or a phenyl group and R2 represents a possibly substituted, straight-chain or branched alkyl group), characterized by reacting a nitrile represented by formula (2)[C6]
R2C≡N  (2)
(wherein R2 represents a possibly substituted, straight-chain or branched alkyl group) with acetone or acetophenone in the presence of iron(III) nitrate.