| US 7,576,207 B2 | ||
| Spirocyclic heterocyclic derivatives and methods of their use | ||
| Roland E. Dolle, King of Prussia, Pa. (US); Bertrand Le Bourdonnec, East Fallowfield, Pa. (US); and Guo-Hua Chu, Exton, Pa. (US) | ||
| Assigned to Adolor Corporation, Exton, Pa. (US) | ||
| Filed on Apr. 04, 2007, as Appl. No. 11/696,585. | ||
| Claims priority of provisional application 60/790416, filed on Apr. 06, 2006. | ||
| Prior Publication US 2007/0269374 A1, Nov. 22, 2007 | ||
| Int. Cl. C07D 401/00 (2006.01); A01N 43/42 (2006.01) | ||
| U.S. Cl. 546—17 [514/278] | 62 Claims |
1. A compound of formula I:
 W is alkylene;
Z is alkoxy, —C(═O)—R2, —NR3—C(═O)—R4, or —NR3S(═O)malkyl;
each R1 is independently carboxy, hydroxy, alkoxy, halo, aminocarbonyl, N-alkylaminocarbonyl, or N,N-dialkylaminocarbonyl;
R2 is —NR5R6 or alkoxy;
R3 and Ra are each independently H or alkyl;
R4 is alkyl or —NR5R6;
R5 and R6 are each independently H or alkyl, or R5 and R6 taken together with the nitrogen atom to which they are connected form a 3- to 8-membered heterocycloalkyl ring in which 1
or 2 of the heterocycloalkyl ring carbon atoms independently may each be optionally replaced by —O—, —S—, —N(R7)—, —N(R8)—C(═O)—, or —C(═O)—N(R9)—;
R7, R8, and R9 are each independently H or alkyl;
X is —CH2— or —O—;
A and B are each H, or taken together with the carbon atoms through which they are connected form a double bond; and
t is 0, 1 or 2;
or a pharmaceutically acceptable salt thereof.
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