| US 7,576,129 B2 | ||
| Carboxylic acid compounds | ||
| Masaki Asada, Mishima-gun (Japan); Kaoru Kobayashi, Mishima-gun (Japan); Masami Narita, Mishima-gun (Japan); Kazutoyo Sato, Mishima-gun (Japan); Atsushi Kinoshita, Mishima-gun (Japan); Toshihiko Nagase, Mishima-gun (Japan); and Ken Yoshikawa, Mishima-gun (Japan) | ||
| Assigned to Ono Pharmaceutical Co., Ltd., Osaka (Japan) | ||
| Appl. No. 10/544,646 PCT Filed Feb. 06, 2004, PCT No. PCT/JP2004/001262 § 371(c)(1), (2), (4) Date Nov. 23, 1995, PCT Pub. No. WO2004/069788, PCT Pub. Date Aug. 19, 2004. |
||
| Claims priority of application No. 2003-031593 (JP), filed on Feb. 07, 2003. | ||
| Prior Publication US 2007/0167498 A1, Jul. 19, 2007 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 31/195 (2006.01); A61K 31/34 (2006.01); C07D 317/44 (2006.01); C07D 335/00 (2006.01); C07C 63/00 (2006.01) | ||
| U.S. Cl. 514—539 [514/563; 546/329; 549/13; 549/32; 549/59; 549/74; 549/426; 549/434; 549/445; 549/469; 560/21; 562/405] | 10 Claims |
1. A carboxylic acid compound of formula (I):
 wherein R1 is hydrogen or C1-4 alkyl;
R2 is phenyl, naphthyl, benzofuranyl or benzothionyl, which is unsubstituted or substituted with 1-2 of C1-4 alkyl and/or halogen;
Q is (i) —CH2—O-Cyc1, (ii) —CH2-Cyc2 or (iii) -L-Cyc3;
Cyc1 is phenyl or pyridyl, which is unsubstituted or substituted with 1-2 of R4;
Cyc2 is indolyl which is unsubstituted or substituted with 1-2 of R4;
Cyc3 is phenyl substituted with 1-2 of R4;
L is —O— or —NH—;
R3a and R3b each independently is hydrogen or C1-4 alkyl or
R3a and R3b, taken together with the carbon atom to which they are attached, form tetrahydro-2H-pyran;
m is 2 or 3;
n is 0, 1 or 2;
R4 is C1-4 alkyl, C1-4 alkylthio, halogen or cyano, or when Cyc3 is phenyl substituted with two R4, two R4 taken together with phenyl may form
 or a salt thereof.
|