US 7,575,918 B2
	Tissue-specific and pathogen-specific ribozymes
James Norris, Mt. Pleasant, S.C. (US); Gary Clawson, Bethesda, Md. (US); Caroline Westwater, Mt. Pleasant, S.C. (US); David Schofield, Mt. Pleasant, S.C. (US); Michael G. Schmidt, Charleston, S.C. (US); Brian Hoel, Charleston, S.C. (US); Joseph Dolan, Mt. Pleasant, S.C. (US); and Wei-Hua Pan, Hummelstown, Pa. (US)
Assigned to The Penn State Research Foundation, University Park, Pa. (US)
Filed on Sep. 08, 2004, as Appl. No. 10/935,962.
Application 10/935962 is a continuation of application No. 09/548449, filed on Apr. 13, 2000, abandoned.
Application 09/548449 is a continuation in part of application No. 09/291902, filed on Apr. 14, 1999, granted, now 6,271,359.
Prior Publication US 2005/0107326 A1, May 19, 2005
Int. Cl. C07H 21/04 (2006.01); C07H 21/02 (2006.01); C12Q 1/68 (2006.01); A61K 31/70 (2006.01)

U.S. Cl. 435—320.1  [435/6; 536/23.1; 536/24.1; 536/24.5; 514/44]

10 Claims

1. A recombinant nucleic acid comprising a tissue-specific promoter operably linked to a ribozyme cassette comprising one or more autocatalytically cleaving ribozyme sequences and a trans-acting cleaving ribozyme sequence comprising a target RNA-specific sequence that cleaves an RNA encoded by SEQ ID NO:19 at a nucleotide selected from the group consisting of nucleotide number 108, nucleotide number 437, and nucleotide number 506.