US 11,721,021 B2
Image analysis of epithelial component of histologically normal prostate biopsies predicts the presence of cancer
David Frazier Jarrard, Madison, WI (US); Bing Yang, Madison, WI (US); and Peter LaViolette, Milwaukee, WI (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US); and The Medical College of Wisconsin, Inc., Milwaukee, WI (US)
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US); and The Medical College of Wisconsin, Inc., Milwaukee, WI (US)
Filed on Aug. 25, 2022, as Appl. No. 17/895,221.
Application 17/895,221 is a continuation of application No. 16/723,595, filed on Dec. 20, 2019, granted, now 11,449,987.
Claims priority of provisional application 62/783,879, filed on Dec. 21, 2018.
Prior Publication US 2022/0414878 A1, Dec. 29, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G06T 7/00 (2017.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01); G01N 1/30 (2006.01)
CPC G06T 7/0012 (2013.01) [G01N 1/30 (2013.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01); G01N 2001/302 (2013.01); G01N 2001/305 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method of detecting and optionally treating prostate cancer in a human subject, the method comprising:
obtaining histologically normal prostate tissue from the subject; and
quantifying, comprising one or more of:
quantifying an increase in epithelial thickness in the tissue of at least 6% relative to the epithelial thickness measured in a sample from a healthy, prostate tumor-free subject; and
quantifying a decrease in gland lumen roundness in the tissue of at least 10% relative to the gland lumen roundness measured in a sample from a healthy, prostate tumor-free subject; and then
performing a prostate cancer detection procedure on the subject.