CPC G01N 33/573 (2013.01) [C12Q 1/25 (2013.01); C12Q 1/6883 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57496 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/9015 (2013.01); G01N 2800/52 (2013.01); G01N 2800/7014 (2013.01)] | 20 Claims |
1. A method of determining the onset, progression, or regression in a subject of a disorder associated with increased threonyl-tRNA synthetase (TARS) expression or activity, the method comprising:
(a) obtaining a first biological sample from a subject;
(b) measuring a level of a TARS molecule in the first biological sample;
(c) obtaining a second biological sample from the subject;
(d) measuring the level of the TARS molecule in the second biological sample obtained from the subject, wherein the second biological sample is obtained from the subject at a time subsequent to the time the first biological sample is obtained;
(e) comparing the measurement of the level of the TARS molecule in the first biological sample to the measurement of the level of the TARS molecule in the second biological sample as a determination of the onset, progression, or regression of the disorder associated with increased TARS activity, wherein an increase in the level of the TARS molecule in the second biological sample compared to the first biological sample indicates onset or progression of the disorder associated with increased TARS activity and a decrease in the level of the TARS molecule in the second biological sample compared to the first biological sample indicates regression of the disorder associated with increased TARS activity,
(f) selecting a treatment regimen for the subject based at least in part on the comparison of the level of the TARS molecule in first and second biological sample; and
(g) carrying out the selected treatment regimen in the subject.
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