US 11,719,668 B2
Functionalized field-effect transistor comprising a molecularly imprinted polymer or a probe material for sensing biomarkers
Johan Frédéric Longo, Yverdon-les-Bains (CH); Neil Ebejer, Lausanne (CH); Hoël Maxime Guérin, Lausanne (CH); and Fabien Patrick Wildhaber, Troistorrents (CH)
Assigned to Xsensio SA, Lausanne (CH)
Appl. No. 16/975,692
Filed by Xsensio SA, Lausanne (CH)
PCT Filed Mar. 6, 2019, PCT No. PCT/EP2019/055613
§ 371(c)(1), (2) Date Aug. 25, 2020,
PCT Pub. No. WO2019/170775, PCT Pub. Date Sep. 12, 2019.
Claims priority of provisional application 62/656,882, filed on Apr. 12, 2018.
Claims priority of provisional application 62/639,449, filed on Mar. 6, 2018.
Prior Publication US 2021/0364466 A1, Nov. 25, 2021
Int. Cl. G01N 27/414 (2006.01); A61B 5/145 (2006.01); A61B 5/00 (2006.01); G01N 33/487 (2006.01)
CPC G01N 27/4145 (2013.01) [G01N 27/4146 (2013.01); G01N 27/4148 (2013.01); A61B 5/14517 (2013.01); A61B 5/4266 (2013.01); G01N 33/48707 (2013.01)] 17 Claims
OG exemplary drawing
 
1. An apparatus for detecting and/or monitoring one or more molecules of interest in a biofluid, the apparatus comprising:
a field-effect transistor disposed on and/or within a substrate, the field-effect transistor comprising one or more metallic gates; and
one or more compositions for selectively sensing at least one of the one or more molecules of interest, wherein:
the one or more compositions comprise a molecularly imprinted polymer (MIP) membrane, and
each of the one or more compositions is disposed on at least a portion of a surface of at least one of the one or more metallic gates,
wherein the MIP membrane comprises (i) a plurality of cavities that are shaped and sized to selectively bind to the one or more molecules of interest and (ii) one or more materials selected from the group consisting of polyvinyl chloride, polystyrene, poly-(3-aminophenylboronic acid) and derivative, polyaniline and derivative, polysiloxane and derivative, polypyrrole, and poly(3,4-ethylenedioxythiophene).