CPC G01N 27/4145 (2013.01) [G01N 27/4146 (2013.01); G01N 27/4148 (2013.01); A61B 5/14517 (2013.01); A61B 5/4266 (2013.01); G01N 33/48707 (2013.01)] | 17 Claims |
1. An apparatus for detecting and/or monitoring one or more molecules of interest in a biofluid, the apparatus comprising:
a field-effect transistor disposed on and/or within a substrate, the field-effect transistor comprising one or more metallic gates; and
one or more compositions for selectively sensing at least one of the one or more molecules of interest, wherein:
the one or more compositions comprise a molecularly imprinted polymer (MIP) membrane, and
each of the one or more compositions is disposed on at least a portion of a surface of at least one of the one or more metallic gates,
wherein the MIP membrane comprises (i) a plurality of cavities that are shaped and sized to selectively bind to the one or more molecules of interest and (ii) one or more materials selected from the group consisting of polyvinyl chloride, polystyrene, poly-(3-aminophenylboronic acid) and derivative, polyaniline and derivative, polysiloxane and derivative, polypyrrole, and poly(3,4-ethylenedioxythiophene).
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