	US 11,718,860 B2
	Synthetic promoters
Timothy Kuan-Ta Lu, Cambridge, MA (US); Lior Nissim, Cambridge, MA (US); and Ming-Ru Wu, Brookline, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Appl. No. 16/493,340
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
PCT Filed Mar. 13, 2018, PCT No. PCT/US2018/022093 § 371(c)(1), (2) Date Sep. 12, 2019, PCT Pub. No. WO2018/169901, PCT Pub. Date Sep. 20, 2018.
Claims priority of provisional application 62/470,754, filed on Mar. 13, 2017.
Prior Publication US 2021/0171977 A1, Jun. 10, 2021
Int. Cl. A01N 63/00 (2020.01); A61K 39/245 (2006.01); C07H 21/04 (2006.01); C12N 15/85 (2006.01); A61K 35/763 (2015.01); C12N 15/86 (2006.01)

CPC C12N 15/85 (2013.01) [A61K 35/763 (2013.01); C12N 15/86 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16643 (2013.01); C12N 2830/008 (2013.01)]

7 Claims

1. An engineered nucleic acid comprising a promoter that comprises the following sequence: TFBS-AGA-TFBS-TCG-TFBS-GAC-TFBS-CTA-TFBS-ACT-TFBS-TGC-TFBS-GTA-TFBS, wherein TFBS comprises the following sequence: CCACGTGC (SEQ ID NO: 12265).