CPC C07D 471/04 (2013.01) | 17 Claims |
1. A compound of Formula I,
or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof,
in which
R1 and R2 are each independently selected from the group consisting of hydrogen, halo, cyano, C1 to C4 alkyl and substituted alkyl;
n is 1, 2, 3, or 4;
R3, R4, R6 are each independently selected from the group consisting of hydrogen, C1 to C6 alkyl and substituted alkyl, aryl and heteroaryl;
R5 is selected from the group consisting of C1 to C6 alkyl and substituted alkyl, aryl and heteroaryl;
R7 is selected from the group consisting of C1 to C6 alkyl and substituted alkyl, C2 to C6 alkenyl and substituted alkenyl, C2 to C6 alkynyl and substituted alkynyl, and acyl having 1 to 6 carbon atoms;
Z is NR8, wherein R8 is selected from hydrogen, C1 to C6 alkyl and substituted alkyl;
A is a saturated four to six membered ring, which is a full carbocyclic ring or a heterocyclic ring containing one oxygen atom, one nitrogen atom, or two nitrogen atoms as ring atoms.
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