US 11,718,615 B2
Heterocyclic compounds and their application in medicine
Dong Liu, Hangzhou (CN)
Assigned to KIND PHARMACEUTICAL, Zhejiang (CN)
Filed by KIND PHARMACEUTICAL, Hangzhou (CN)
Filed on Dec. 7, 2021, as Appl. No. 17/544,805.
Application 17/544,805 is a continuation of application No. 16/762,478, granted, now 11,236,088, previously published as PCT/CN2018/115142, filed on Nov. 13, 2018.
Claims priority of application No. 201711123800.2 (CN), filed on Nov. 14, 2017.
Prior Publication US 2022/0098195 A1, Mar. 31, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/04 (2006.01)
CPC C07D 471/04 (2013.01) 17 Claims
 
1. A compound of Formula I,

OG Complex Work Unit Chemistry
or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof,
in which
R1 and R2 are each independently selected from the group consisting of hydrogen, halo, cyano, C1 to C4 alkyl and substituted alkyl;
n is 1, 2, 3, or 4;
R3, R4, R6 are each independently selected from the group consisting of hydrogen, C1 to C6 alkyl and substituted alkyl, aryl and heteroaryl;
R5 is selected from the group consisting of C1 to C6 alkyl and substituted alkyl, aryl and heteroaryl;
R7 is selected from the group consisting of C1 to C6 alkyl and substituted alkyl, C2 to C6 alkenyl and substituted alkenyl, C2 to C6 alkynyl and substituted alkynyl, and acyl having 1 to 6 carbon atoms;
Z is NR8, wherein R8 is selected from hydrogen, C1 to C6 alkyl and substituted alkyl;
A is a saturated four to six membered ring, which is a full carbocyclic ring or a heterocyclic ring containing one oxygen atom, one nitrogen atom, or two nitrogen atoms as ring atoms.