CPC A61K 41/0033 (2013.01) [A61K 9/1271 (2013.01); A61K 47/12 (2013.01); A61K 47/24 (2013.01); A61N 7/00 (2013.01); A61N 2007/0039 (2013.01)] | 14 Claims |
1. A freeze-dried formulation, for preparing gas-filled microvesicles, comprising a mixture of the following lipid components: (a) distearoyl-phosphatidylcholine (DSPC), (b) dipalmitoylphosphatidyl-ethanolamine conjugated with polyethyleneglycol having a Mw of 5000 g/mol (DPPE-PEG5000) and (c) palmitic acid; said lipid components being in a respective molar amount a/b/c of 65 to 85/4 to 10/8 to 22,
wherein the formulation further comprises polyethylene glycol 4000 g/mol (PEG4000), and wherein the mixture of lipid components has a weight of from more than 0.3% to 0.5% with respect to the weight of PEG4000.
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