CPC A61K 39/04 (2013.01) [A61P 31/06 (2018.01); C12N 1/20 (2013.01); C12N 1/205 (2021.05); C12R 2001/32 (2021.05)] | 9 Claims |
1. A live recombinant Mycobacterium bovis-BCG strain comprising nucleic acids capable of overexpression and overexpressing both PhoP and PhoR proteins, the recombinant Mycobacterium bovis-BCG strain having improved immunogenicity compared to wild type nonrecombinant Mycobacterium bovis-BCG strain, the recombinant Mycobacterium bovis-BCG strain having virulence comparable with wild type nonrecombinant Mycobacterium bovis-BCG strain, and the recombinant Mycobacterium bovis-BCG strain having a decreased virulence compared to recombinant Mycobacterium bovis-BCG strain overexpressing only PhoP.
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