CPC A61K 38/18 (2013.01) [A61K 47/65 (2017.08); A61P 19/08 (2018.01); C07K 14/71 (2013.01); C07K 14/76 (2013.01); C12N 15/85 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01); A61K 47/64 (2017.08)] | 12 Claims |
1. A nucleic acid molecule encoding a polypeptide comprising an extracellular activin receptor type IIa (ActRIIa) variant and an Fc domain, the variant having a sequence of
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wherein X1 is F or Y; X2 is Y; X3 is E; X4 is L; X5 is D or E; X6 is R; X7 is P or R; X8 is E; X9 is E; X10 is K or Q; X11 is D; X12 is K; X13 is R; X14 is L; X15 is F or Y; X16 is K or R; X17 is K; X18 is K; X19 is W; X20 is L; X21 is D; X22 is I or F; X23 is T; X24 is K or E; X25 is E; X26 is N; and X27 is Q.
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