US 7,572,903 B1
	Method of regulation of bacterial persister status
Peter Gilbert, Cheshire (United Kingdom); Alexander H. Rickard, Binghamton, N.Y. (US); Michael Kertesz, Sale (United Kingdom); and Sharon Lindsay, Liverpool (United Kingdom)
Assigned to S.C. Johnson & Son, Inc., Racine, Wis. (US)
Filed on Aug. 17, 2006, as Appl. No. 11/505,644.
Claims priority of provisional application 60/709224, filed on Aug. 18, 2005.
Int. Cl. C07H 21/04 (2006.01); C07H 21/02 (2006.01); C12N 9/00 (2006.01); C12N 15/01 (2006.01)

U.S. Cl. 536—23.7  [424/9.1; 424/9.2; 435/183; 435/440; 435/441; 435/446; 435/471; 536/23.1]

8 Claims

1. A method of identifying compounds that alter bacterial persister status, the method comprising the step of identifying compounds that modulate the expression of a gene selected from E. coli genes mcrA, lit, pin, ykgM and ykgK or inhibit or enhance the functional activity of the protein products of these genes.