| US 7,572,897 B2 | ||
| Antibodies against insulin-like growth factor I receptor and uses thereof | ||
| Yvo Graus, Ede (Netherlands); Erhard Kopetzki, Penzberg (Germany); Klaus-Peter Kuenkele, Benediktbeuern (Germany); Olaf Mundigl, Weilheim (Germany); Paul Parren, Odijk (Netherlands); Frank Rebers, Utrecht (Netherlands); Ralf Schumacher, Penzberg (Germany); Jan van de Winkel, Zeist (Netherlands); and Martine Vriesema-van Vugt, Houten (Netherlands) | ||
| Assigned to Hoffman-La Roche Inc., Nutley, N.J. (US) | ||
| Filed on Oct. 09, 2007, as Appl. No. 11/869,250. | ||
| Application 11/869250 is a division of application No. 10/886838, filed on Jul. 08, 2004. | ||
| Claims priority of application No. 03015526 (EP), filed on Jul. 10, 2003. | ||
| Prior Publication US 2008/0132686 A1, Jun. 05, 2008 | ||
| Int. Cl. C07K 16/28 (2006.01) | ||
| U.S. Cl. 530—388.15 [530/388.22; 530/388.8] | 6 Claims |
| 1. A purified monoclonal antibody that binds to the IGF-IR which comprises
a heavy chain comprising
a first complementarity determining region consisting of amino acids 31 to 35 of said heavy chain having an amino acid sequence
consisting of amino acids 31 to 35 of SEQ ID NO:1,
a second complementarity determining region consisting of amino acids 50 to 66 of said heavy chain having an amino acid sequence
consisting of amino acids 50 to 66 of SEQ ID NO:1, and
a third complementarity determining region consisting of amino acids 99 to 107 of said heavy chain having an amino acid sequence
consisting of amino acids 99 to 107 of SEQ ID NO:1; and
a light chain comprising
a first light chain complementarity determining region consisting of amino acids 24 to 34 of said light chain having an amino
acid sequence consisting of amino acids 24 to 34 of SEQ ID NO:2,
a second light chain complementarity determining region consisting of amino acids 50 to 56 of said light chain having an amino
acid sequence consisting of amino acids 50 to 56 of SEQ ID NO:2, and
a third light chain complementarity determining region consisting of amino acids 89 to 98 of said light chain having an amino
acid sequence consisting of amino acids 89 to 98 of SEQ ID NO:2.
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