US 7,572,803 B2
Hydrated crystalline esters of camptothecin
Zhisong Cao, Friendswood, Tex. (US)
Assigned to The Christus Stehlin Foundation for Cancer Research, Houston, Tex. (US)
Filed on Oct. 25, 2007, as Appl. No. 11/923,727.
Prior Publication US 2009/0111845 A1, Apr. 30, 2009
Int. Cl. A61K 31/4745 (2006.01); C07D 491/22 (2006.01)
U.S. Cl. 514—283  [546/48] 19 Claims
 
1. A crystalline camptothecin hydrate of formula (I):

OG Complex Work Unit Drawing
wherein n is a number ranging from 1 to 10, and R1 is C2-C6 alkyl group.