US 7,572,762 B1
	Materials and methods relating to the induction of apoptosis in target cells
Barbara Ann Spruce, Perth (United Kingdom); Neil Donald Perkins, Dundee (United Kingdom); Jayne Samson, Dundee (United Kingdom); and Niall McTavish, Tayport (United Kingdom)
Assigned to University of Dundee, Dundee (United Kingdom)
Appl. No. 9/720,851 PCT Filed Jun. 29, 1999, PCT No. PCT/GB99/02045 § 371(c)(1), (2), (4) Date Apr. 06, 2001, PCT Pub. No. WO00/00599, PCT Pub. Date Jan. 06, 2000.
Claims priority of application No. 9814036.1 (GB), filed on Jun. 29, 1998.
Int. Cl. A61K 38/00 (2006.01); A61K 31/40 (2006.01)

U.S. Cl. 514—2  [514/408]

12 Claims

1. A method for the preferential induction of apoptosis in a first population of cells in a human compared to a second population of cells in said human said method comprising exposing said first and second population of cells to at least one sigma receptor ligand, wherein said sigma receptor ligand produces a cytotoxic effect without chemical modification to impart a cytotoxic effect thereto, wherein the cells of said first population are tumour cells, wherein the cells of the first population are p53 null tumor cells, and said method further comprising exposing the cells to an agonist for a kappa receptor.