| US 7,572,621 B2 | ||
| Detection, characterization and treatment of viral infection and methods thereof | ||
| Yu-wen Hu, Ottawa (Canada); and Earl Brown, Ottawa (Canada) | ||
| Assigned to Canadian Blood Services, (Canada) | ||
| Filed on Oct. 11, 2005, as Appl. No. 11/248,008. | ||
| Application 11/248008 is a continuation of application No. PCT/CA2004/000544, filed on Apr. 13, 2004. | ||
| Claims priority of provisional application 60/461137, filed on Apr. 09, 2003. | ||
| Claims priority of provisional application 60/506779, filed on Sep. 30, 2003. | ||
| Prior Publication US 2006/0115875 A1, Jun. 01, 2006 | ||
| Int. Cl. C12N 7/00 (2006.01) | ||
| U.S. Cl. 435—235.1 | 6 Claims |
| 1. A method of characterizing an hepatitis C viral infection, said method comprising:
determining a similarity between a viral sequence of an hypervariable region 1 (HVR1) of the second envelope protein (E2)
region of an hepatitis C virus that infected the host and a variable region kappa light chain of an immunoglobulin (IgVLκ)
of the host; and
wherein, when said similarity is at least 20%, said hepatitis C viral infection is characterized as persistent; and when said
similarity is not at least 20%, said hepatitis C viral infection is characterized as acute.
|