US 7,572,463 B2
	Oral dosage forms
Johannes Bartholomaeus, Aachen (Germany); and Iris Ziegler, Rott-Roetgen (Germany)
Assigned to Gruenenthal GmbH, Aachen (Germany)
Filed on Feb. 28, 2002, as Appl. No. 10/84,674.
Application 10/084674 is a continuation of application No. PCT/EP00/08402, filed on Aug. 29, 2000.
Claims priority of application No. 199 40 740 (DE), filed on Aug. 31, 1999; application No. 199 40 944 (DE), filed on Aug. 31, 1999; and application No. 100 23 699 (DE), filed on May 16, 2000.
Prior Publication US 2002/0176888 A1, Nov. 28, 2002
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/22 (2006.01)

U.S. Cl. 424—468  [424/400; 424/464; 424/465]

65 Claims

1. A controlled-release oral dosage formulation of a salt-forming active ingredient, wherein the active ingredient is present as at least two different salts in a solid aggregation state from which the active ingredient is released by dissolution of said salts, wherein the two different salts have different water solubility and release the active ingredient in-vitro at different release rates, provided that oral dosage formulations are excluded which comprise a resin carrying a sulfonate group and a resin carrying a carboxyl group and which contain an active ingredient in a form fixed to these resins, and wherein the water solubilities of the at least two different salts differ from one another at least by a factor of 2.