| US 7,572,451 B2 | ||
| Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof | ||
| Martin F. Bachmann, Seuzach (Switzerland); Alma Fulurija, Zürich-Schlieren (Switzerland); and Philippe Saudan, Pfungen (Switzerland) | ||
| Assigned to Cytos Biotechnology AG, Zürich-Schlieren (Switzerland) | ||
| Filed on Oct. 25, 2005, as Appl. No. 11/257,498. | ||
| Claims priority of provisional application 60/621465, filed on Oct. 25, 2004. | ||
| Prior Publication US 2006/0088550 A1, Apr. 27, 2006 | ||
| Int. Cl. A61K 39/385 (2006.01); A61K 39/00 (2006.01); C12P 21/06 (2006.01); C07H 21/04 (2006.01) | ||
| U.S. Cl. 424—185.1 [424/193.1; 424/198.11; 435/69.1; 536/23.4; 536/23.51; 536/23.75] | 69 Claims |
| 1. A composition comprising:
(a) a virus-like particle (VLP) of an RNA-bacteriophage with at least one first attachment site; and
(b) at least one antigen with at least one second attachment site,
wherein said at least one antigen is selected for its ability to induce an immune response against gastric inhibitory polypeptide
(GIP) when linked to said VLP,
and wherein said at least one antigen is a GIP protein or a GIP fragment;
and wherein (a) and (b) are linked through said at least one first and said at least one second attachment site,
wherein said composition, when administered to a mammal, induces an immune response against GIP.
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