US 7,569,688 B2
Propane-1, 3-dione derivative
Masaaki Hirano, Tsukuba (Japan); Eiji Kawaminami, Tsukuba (Japan); Akira Toyoshima, Tsukuba (Japan); Hiroyuki Moritomo, Tsukuba (Japan); Norio Seki, Tsukuba (Japan); Ryutaro Wakayama, Tsukuba (Japan); Minoru Okada, Tsukuba (Japan); and Toshiyuki Kusayama, Tsukuba (Japan)
Assigned to Astellas Pharma Inc., Tokyo (Japan)
Filed on Jun. 20, 2005, as Appl. No. 11/155,595.
Application 11/155595 is a division of application No. 10/311688, granted, now 6,960,591, previously published as PCT/JP01/05813, filed on Jul. 04, 2001.
Claims priority of application No. 2000-204425 (JP), filed on Jul. 05, 2000; and application No. 2001-153372 (JP), filed on May 23, 2001.
Prior Publication US 2005/0267110 A1, Dec. 01, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 235/06 (2006.01); C07D 401/06 (2006.01)
U.S. Cl. 544—242  [544/333; 544/336; 544/405; 546/118; 546/174; 546/199; 546/256; 546/273.4; 548/180; 548/181; 548/304.4; 548/304.7; 548/305.4; 548/306.1; 548/310.4; 514/255.05; 514/256; 514/303; 514/314; 514/322; 514/333; 514/338; 514/365; 514/367; 514/394] 3 Claims
 
1. A propane-1,3-dione compound represented by the general formula (I):

OG Complex Work Unit Drawing
(R1, R2, R3 and R4: the same or different, H, NO2, CN, Halo, a hydrocarbon group which may be substituted, a heterocycle which may be substituted, a hydroxy which may be substituted, a carboxy which may be substituted, an acyl-O— which may be substituted, an acyl which may be substituted, a substituent —S(O)n101— (n101: an integer of 0 to 2, the same shall apply hereinafter), H—S(O)n101—, a carbamoyl which may be substituted, a sulfamoyl which may be substituted, or an amino which may be substituted, and two adjacent groups selected from the group of R1, R2, R3 and R4 may be combined to form an aryl or a cycloalkenyl; R5 and R6: the same or different, H, Halo, a hydrocarbon group which may be substituted or an amino which may be substituted; X1 and X2: the same or different, N, S or O atom; A and B: the same or different, an aryl which may be substituted or a heterocycle which may be substituted; Z1, Z2, Z3 and Z4: C or N; provided that 1) when X1 and X2 each is S or O, one or both of the corresponding R5 and R6 are absent; 2) when one to four of Z1, Z2, Z3 and/or Z4 are N, the corresponding R1, R2, R3 and/or R4 are absent; and 3) that if one of A and B is phenyl, the other is not 4-nitrophenyl)
or a pharmaceutically acceptable salt thereof, provided that the compounds 1 to 39 shown in the following table are excluded, wherein the symbol Ph means phenyl, Me means methyl, Et means ethyl, and tBu means tert-butyl,
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