US 7,569,547 B2
	Inhibiting furin with polybasic peptides
Iris Lindberg, Baltimore, Md. (US); Angus Cameron, Bristol (United Kingdom); Richard A. Houghten, Vero Beach, Fla. (US); and Jon Richard Appel, Cardiff, Calif. (US)
Assigned to Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, La. (US); and Torrey Pines Institute for Molecular Studies, San Diego, Calif. (US)
Filed on Apr. 21, 2006, as Appl. No. 11/408,519.
Application 11/408519 is a division of application No. 09/906311, filed on Jul. 16, 2001, granted, now 7,033,991.
Prior Publication US 2006/0241050 A1, Oct. 26, 2006
Int. Cl. A61K 38/00 (2006.01); C07K 16/00 (2006.01)

U.S. Cl. 514—13  [514/14; 514/15; 514/16; 514/17; 514/18; 530/326; 530/327; 530/328; 530/329; 530/330]

9 Claims

1. A method for inhibiting the growth or metastasis of a tumor in a mammalian host, wherein the growth or metastasis of the tumor depends upon furin; said method comprising administering to a human host a polyarginine, wherein the polyarginine is from four to twenty arginine residues; wherein the host has a tumor; wherein the growth or metastasis of the tumor depends upon furin; and wherein the amount of the polyarginine administered to the host is an effective amount for inhibiting the growth or metastasis of the tumor.