	US 7,569,392 B2
	Multiplex spatial profiling of gene expression
Shawn Levy, Hendersonville, Tenn. (US); and Richard M. Caprioli, Brentwood, Tenn. (US)
Assigned to Vanderbilt University, Nashville, Tenn. (US)
Filed on Jan. 07, 2005, as Appl. No. 11/31,973.
Claims priority of provisional application 60/535075, filed on Jan. 08, 2004.
Prior Publication US 2005/0196786 A1, Sep. 08, 2005
Int. Cl. C12Q 1/68 (2006.01); G01N 33/53 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07K 16/00 (2006.01); C07K 2/00 (2006.01); C12N 15/11 (2006.01); C07K 17/02 (2006.01)

U.S. Cl. 436—6 [435/7.1; 530/387.1; 530/350; 530/324; 536/23.1]

40 Claims

1. A mass tag complex comprising:

(i) a water-soluble core structure;

(ii) a target binding agent;

(iii) a mass unit that permits detection by mass spectroscopy; and

(iv) a cleavage site connected to said mass unit.