	US 7,569,238 B2
	Antitussive agent and method for making the same
Feng-Nien Ko, Taipei (Taiwan); Wei-Ja Wang, Taipei (Taiwan); Cheng-Ko Liu, Shindian (Taiwan); Pin-Fen Chen, Taipei (Taiwan); Yu-Feng Han, Taichung (Taiwan); and Mai-Yu Lee, Taipei (Taiwan)
Assigned to Pharmaceutical Industry Technology and Development Center, Taipei Hsien (Taiwan)
Filed on Apr. 28, 2003, as Appl. No. 10/423,966.
Prior Publication US 2004/0213863 A1, Oct. 28, 2004
Int. Cl. A61K 36/00 (2006.01)

U.S. Cl. 424—773 [424/725]

12 Claims

1. A pharmaceutical composition comprising an effective amount of an extract of a Radix Cynanchi atrati and a pharmaceutically acceptable carrier or excipient; wherein said extract is an eluate of said Radix Cynanchi atrati prepared by the steps of:

extracting said Radix Cynanchi atrati with water, ethanol, ethyl acetate, hexane or a combination thereof to obtain a crude extract;

loading said crude extract onto a reverse phase column;

eluting said reverse phase column with water and an 80-95% ethanol solution sequentially to collect said eluate of said Radix Cynanchi atrati.