| US 7,569,051 B2 | ||
| Apparatus for piezoelectric layer-wise pump and valve for use in local administration of biological response modifiers and therapeutic agents | ||
| Yehoshua Shachar, Santa Monica, Calif. (US) | ||
| Assigned to Pharmaco Kinesis Corporation, Inglewood, Calif. (US) | ||
| Filed on Dec. 18, 2007, as Appl. No. 11/959,405. | ||
| Application 11/959405 is a division of application No. 10/614685, filed on Jul. 03, 2003. | ||
| Claims priority of provisional application 60/393933, filed on Jul. 03, 2002. | ||
| Prior Publication US 2008/0089920 A1, Apr. 17, 2008 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 9/32 (2006.01); A61M 31/00 (2006.01); F04B 17/00 (2006.01) | ||
| U.S. Cl. 604—891.1 [604/65; 417/413.2] | 9 Claims |
| 1. An implantable apparatus for infusing a plurality of medicating agents to a specific desired location at a tumor site for
non-systemic treatment of a tumor, when implanted within a patient's body, comprising:
an implantable pouch having one or more collapsible and disintegratable chambers composed of a bioabsorbable material, the
chambers being structurally defined by a matrix, each chamber for storing a corresponding one of the plurality of the medicating
agents in a macroscopic amount sufficient for tumor treatment, and wherein the chambers are arranged and configured to substantially
completely collapse and disintegrate within the patient's body with depletion of the plurality of medicating agents which
is selectively dispensed from the chambers;
at least one of the plurality of medicating agents are stored in corresponding ones of the plurality of one or more collapsible
chambers;
at least one implantable piezoelectric pump fabricated in the pouch which forms a skeleton of the pump, the pump being configured
to transfer said at least one medicating agent to the patient;
an implantable, syngeneic and biodegradable human skin substitute covering the pouch and pump, wherein the biodegradable human
skin substitute is arranged and configured to substantially completely collapse and disintegrate within the patient's body
with depletion of the plurality of medicating agents which are selectively dispensed from the chambers; and
a sensor and control logic on a biodegradable substrate housed within and implanted at the site of implantation of the pouch
to monitor biometric measures and indications of the homeostatic response related to at least one of the plurality of medicating
agents at the treatment site,
where the control logic including a programmable memory controls that at least one piezoelectric pump to modify the state
of the tumor in response to measurements from the implanted sensor, and where the control logic controls and selectively adjusts
the dose amounts and scheduling with which the medicating agents are delivered in response to selective user commands delivered
to the control logic and alterable during a treatment process after implantation.
|