| US 7,566,724 B2 | ||
| Glycine derivative and use thereof | ||
| Noriyuki Hirano, Yokohama (Japan); Hideki Inoue, Kamakura (Japan); Takashi Nagahara, Kamakura (Japan); Tomofumi Ohyama, Kamakura (Japan); Mie Kaino, Fujisawa (Japan); Kenichi Hayashi, Kamakura (Japan); Sunao Hara, Kamakura (Japan); and Ryutaro Suzuki, Otsu (Japan) | ||
| Assigned to Toray Industries, Inc., (Japan) | ||
| Appl. No. 11/793,841 PCT Filed Dec. 22, 2005, PCT No. PCT/JP2005/023577 § 371(c)(1), (2), (4) Date Jun. 22, 2007, PCT Pub. No. WO2006/068213, PCT Pub. Date Jun. 29, 2006. |
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| Claims priority of application No. 2004-372880 (JP), filed on Dec. 24, 2004. | ||
| Prior Publication US 2008/0085910 A1, Apr. 10, 2008 | ||
| Int. Cl. C07D 239/34 (2006.01); A61K 31/335 (2006.01); A61K 31/351 (2006.01); A61K 31/505 (2006.01) | ||
| U.S. Cl. 514—274 [514/275; 514/459; 514/460; 544/316; 544/331; 544/332; 549/346; 549/419] | 6 Claims |
1. A compound of the Formula (I):
 R1 represents hydrogen or C1-C5 alkyl;
Xs independently represent fluoro, chloro, bromo, iodo or C1-C3 alkyl;
V represents —CH═CH— or —C≡C—;
Y represents Formula (II) or Formula (III):
 R2 represents C1-C5 alkyl or C1-C3 alkoxy;
R3 represents hydrogen or C1-C5 alkyl;
m represents an integer of 0 to 3;
n represents an integer of 0 or 1;
p represents an integer of 0 to 2;
W represents —O— or —N(R4)—
(wherein
R4 represents hydrogen, C1-C5 alkyl, C3-C6 alkenyl, phenyl, benzyl, benzyl substituted with one or two R5s, tetrahydropyranyl, —(CH2)q—O—CH3, pyridylmethyl, —(CH2)q—CN, C4-C7 cycloalkylmethyl or thiazol-4-ylmethyl;
R5 represents hydroxy or C1-C3 alkoxy; and
q represents an integer of 1 to 3))] or a pharmaceutically acceptable salt thereof.
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