US 7,566,714 B2
	Methods and compositions for the treatment of metabolic disorders
Daniel I. Oppenheimer, Castro Valley, Calif. (US); Emil D. Kakkis, Novato, Calif. (US); Fredric D. Price, Bedford, N.Y. (US); Alejandro Dorenbaum, Mill Valley, Calif. (US); Rudolf Moser, Schaffhausen (Switzerland); Viola Groehn, Dachsen (Switzerland); Thomas Egger, Kempthal (Switzerland); and Fritz Blatter, Reinach (Switzerland)
Assigned to Biomarin Pharmaceutical Inc., Novato, Calif. (US)
Filed on Jun. 01, 2005, as Appl. No. 11/143,887.
Application 11/143887 is a continuation of application No. 10/991573, filed on Nov. 17, 2004, abandoned.
Claims priority of provisional application 60/520767, filed on Nov. 17, 2003.
Prior Publication US 2006/0040946 A1, Feb. 23, 2006
Int. Cl. A61K 31/495 (2006.01)

U.S. Cl. 514—249  [514/250]

46 Claims

1. A method for treating a subject with hyperphenylalaninemia due to tetrahydrobiopterin-responsive phenylketonuria, comprising administering to said subject a therapeutically effective total daily dosage of tetrahydrobiopterin (BH4) or pharmaceutically acceptable salt thereof, wherein the administering is multiday, oral, and only once per day, and wherein the administering does not achieve controlled release of the BH4 in the gastrointestinal tract.