| US 7,566,711 B2 | ||
| Reverse-turn mimetics and method relating thereto | ||
| Sung Hwan Moon, Suwon-shi (Korea, Republic of); Jae Uk Chung, Suwon-shi (Korea, Republic of); Sung Chan Lee, Suwon-shi (Korea, Republic of); Masakatsu Eguchi, Bellevue, Wash. (US); Michael Kahn, Kirkland, Wash. (US); Kwang Won Jeong, Seoul (Korea, Republic of); Cu Nguyen, Arlington, Wash. (US); and Soo Jin Lee, Suwon-shi (Korea, Republic of) | ||
| Assigned to Choongwae Pharma Corporation, Seoul (Korea, Republic of) | ||
| Filed on Apr. 15, 2005, as Appl. No. 11/108,164. | ||
| Application 11/108164 is a continuation in part of application No. 10/826972, filed on Apr. 16, 2004. | ||
| Application 10/826972 is a continuation in part of application No. 10/803179, filed on Mar. 17, 2004. | ||
| Application 10/803179 is a continuation in part of application No. 10/411877, filed on Apr. 09, 2003, abandoned. | ||
| Application 10/411877 is a continuation in part of application No. 10/087443, filed on Mar. 01, 2002, abandoned. | ||
| Application 10/087443 is a continuation in part of application No. 09/976470, filed on Oct. 12, 2001, abandoned. | ||
| Claims priority of application No. PCT/KR02/01901 (WO), filed on Oct. 11, 2002. | ||
| Prior Publication US 2007/0043052 A1, Feb. 22, 2007 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C07D 487/04 (2006.01); A61K 31/53 (2006.01); A61P 35/00 (2006.01) | ||
| U.S. Cl. 514—243 [544/184] | 3 Claims |
| 1. A compound having the following general formula (VII)
—Y—R10 (VI)
wherein (VI) is the formula:
 wherein when not linked to R10,
Ra is a phenyl group; a substituted phenyl group having one or more substituents wherein the one or more substituents are independently
selected from one or more of amino, amidino, guanidino, hydrazino, amidazonyl, C1-4alkylamino, C1-4dialkylamino, halogen, perfluoro C1-4alkyl, C1-4alkyl, C1-3alkoxy, nitro, carboxy, cyano, sulfuryl, and hydroxyl groups; a benzyl group; a substituted benzyl group with one or more
substituents where the one or more substituents are independently selected from one or more of amino, amidino, guanidino,
hydrazino, amidazonyl, C1-4alkylamino, C1-4dialkylamino, halogen, perfluoro C1-4alkyl, C1-3alkoxy, nitro, carboxy, cyano, sulfuryl, and hydroxyl group; or a bicyclic aryl group having 8 to 11 ring members, which may
have 1 to 3 heteroatoms selected from nitrogen, oxygen or sulfur;
Rb is a monocyclic aryl group having 5 to 7 ring members, which may have 1 to 2 heteroatoms selected from nitrogen, oxygen or
sulfur, and aryl ring in the compound may have one or more substituents selected from a group consisting of halide, hydroxy,
cyano, lower alkyl, and lower alkoxy groups;
Rc is a saturated or unsaturated C1-6alkyl, C1-6alkoxy, perfluoro C1-6alkyl group; and
X1, X2, and X3 may be the same or different and independently selected from hydrogen, hydroxyl, and halide; and
Wherein one of Ra, Rb, Rc, X1, X2, and X3 is linked to R10 via Y,
Y is an oxygen, sulfur, or nitrogen in Ra, Rb, and Rc, or an oxygen in X1, X2 and X3; and
Y—R10 is hemimalate, dimethylaminoalkylcarbamates, or a salt thereof; or R10 is hydroxyalkyl, glycosyl, substituted or unsubstituted piperidine oxycarbonyl, or a salt thereof.
|