US 7,402,439 B2
Method of operating an integrated structure of multilayer flow microchannel
Takehiko Kitamori, Tokyo (Japan); Manabu Tokeshi, Kawasaki (Japan); and Akihide Hibara, Tokyo (Japan)
Assigned to Kanagawa Academy of Science and Technology, Kanagawa (Japan)
Appl. No. 10/483,233
PCT Filed Jul. 10, 2002, PCT No. PCT/JP02/00083
§ 371(c)(1), (2), (4) Date Jun. 15, 2004,
PCT Pub. No. WO03/008981, PCT Pub. Date Jan. 30, 2003.
Claims priority of application No. 2001-209932 (JP), filed on Jul. 10, 2001.
Prior Publication US 2004/0219078 A1, Nov. 04, 2004
Int. Cl. G01N 1/10 (2006.01); B01J 10/00 (2006.01)
U.S. Cl. 436—180  [422/129; 422/190; 422/191; 422/198; 422/200] 7 Claims
OG exemplary drawing
 
1. A method for multilayer flow operation to perform microanalysis or chemical synthesis,
the method utilizing a substrate having arranged thereon a first multilayer flow microchannel in which a parallel multilayer flow having at least one interface of fluids is formed, and a second multilayer flow microchannel in which a parallel multilayer flow having at least one interface of fluids is formed, the first multilayer flow microchannel and the second multilayer flow microchannel being in communication with each other, wherein a microprojection is formed at a bottom of at least one of the first multilayer flow microchannel and the second multilayer flow microchannel, the microprojection being formed at a position substantially corresponding to positions of parallel interfaces of the fluids forming the multilayer flow in at least one of the first multilayer flow microchannel and the second multilayer flow microchannel, and extending in a flow direction,
the method for multilayer flow operation comprising performing an extraction or a chemical reaction that involves a transfer of an analyte, a reactant or a product from one fluid layer within the first multilayer flow microchannel to another fluid layer within the first multilayer flow microchannel, and performing an extraction or a chemical reaction that involves a transfer of an analyte, a reactant or a product from one fluid layer within the second multilayer flow microchannel to another fluid layer within the second multilayer flow microchannel.