	US 11,702,674 B2
	Simian adenovirus vectors comprising the ChAd-157 fiber protein
Virginia Ammendola, Rome (IT); Stefania Capone, Rome (IT); Stefano Colloca, Rome (IT); Antonella Folgori, Rome (IT); and Rossella Merone, Rome (IT)
Assigned to GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart (BE)
Appl. No. 16/973,630
Filed by GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart (BE)
PCT Filed Jun. 11, 2019, PCT No. PCT/IB2019/054857 § 371(c)(1), (2) Date Dec. 9, 2020, PCT Pub. No. WO2019/239311, PCT Pub. Date Dec. 19, 2019.
Claims priority of application No. 18177412 (EP), filed on Jun. 12, 2018.
Prior Publication US 2021/0246468 A1, Aug. 12, 2021
Int. Cl. C12N 15/86 (2006.01); A61K 39/235 (2006.01); A61P 37/04 (2006.01); A61K 39/21 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01)

CPC C12N 15/86 (2013.01) [A61K 39/235 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 2039/5256 (2013.01); A61P 37/04 (2018.01); C12N 2710/10322 (2013.01); C12N 2710/10334 (2013.01); C12N 2710/10343 (2013.01); C12N 2740/16034 (2013.01); C12N 2740/16071 (2013.01)]

24 Claims

1. An isolated recombinant polynucleotide simian adenoviral vector, wherein the polynucleotide encodes a polypeptide having the amino acid sequence according to SEQ ID NO: 1, and

further encodes a heterologous polypeptide and the polynucleotide encoding the heterologous polypeptide is operatively linked to one or more sequences which direct expression of the heterologous polypeptide.