CPC C12N 5/0636 (2013.01) [C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/28 (2013.01); C12N 15/90 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/70 (2013.01)] | 15 Claims |
1. An antigen receptor, which receptor comprises a first peptide chain and a second peptide chain,
wherein:
(i) the first peptide chain comprises an immunoglobulin heavy chain variable domain (VH), an immunoglobulin light chain variable domain (VL), a variable region of a T cell receptor chain, and an immunoreceptor signal transmission domain, and
the second peptide chain comprises an immunoglobulin heavy chain variable domain (VH), an immunoglobulin light chain variable domain (VL), a variable region of a T cell receptor chain, and an immunoreceptor signal transmission domain, and
wherein the VH domain from the first peptide chain forms together with the VL domain from the second peptide chain a first antigen binding site, and
wherein the VL domain from the first peptide chain forms together with the VH domain from the second peptide chain a second antigen binding site; or
(ii) the first peptide chain comprises two immunoglobulin light chain variable domains (VL), a variable region of a T cell receptor chain, and an immunoreceptor signal transmission domain, and
the second peptide chain comprises two immunoglobulin heavy chain variable domains (VH), a variable region of a T cell receptor chain, and an immunoreceptor signal transmission domain, and
wherein a first VL domain from the first peptide chain forms a first antigen binding site together with a first VH domain from the second peptide chain, and
wherein a second VL domain from the first peptide chain forms a second antigen binding site together with a second VH domain from the second peptide chain.
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