US 11,702,466 B2
Fusion protein comprising a blood-brain barrier (BBB)-crossing single domain antibody Fc5, an immunoglobulin Fc fragment and a beta-amyloid binding polypeptide (ABP)
Balu Chakravarthy, Ottawa (CA); Danica Stanimirovic, Ottawa (CA); and Yves Durocher, Montreal (CA)
Assigned to National Research Council of Canada, Ottawa (CA)
Appl. No. 16/481,898
Filed by National Research Council of Canada, Ottawa (CA)
PCT Filed Jan. 30, 2018, PCT No. PCT/IB2018/050576
§ 371(c)(1), (2) Date Jul. 30, 2019,
PCT Pub. No. WO2018/138709, PCT Pub. Date Aug. 2, 2018.
Claims priority of provisional application 62/530,980, filed on Jul. 11, 2017.
Claims priority of provisional application 62/452,015, filed on Jan. 30, 2017.
Prior Publication US 2019/0352383 A1, Nov. 21, 2019
Int. Cl. C07K 16/46 (2006.01); C07K 16/00 (2006.01); C07K 14/00 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01); C07K 16/18 (2006.01); A61K 9/00 (2006.01); C07K 14/47 (2006.01)
CPC C07K 16/18 (2013.01) [A61K 9/0019 (2013.01); C07K 14/4711 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2319/10 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/70 (2013.01)] 8 Claims
 
1. A fusion protein comprising the amino acid sequence of SEQ ID NO: 47.