CPC C07K 14/71 (2013.01) [C07K 7/04 (2013.01); C07K 14/001 (2013.01); C07K 14/435 (2013.01); C12N 5/0667 (2013.01); C12N 9/2497 (2013.01); C12N 15/63 (2013.01); C12N 15/85 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/06 (2013.01); C07K 2319/74 (2013.01); C07K 2319/80 (2013.01); C12N 15/11 (2013.01); C12N 2500/25 (2013.01); C12N 2510/00 (2013.01)] | 17 Claims |
1. A fusion polypeptide, comprising:
i. a cell surface receptor-binding peptide, wherein the cell surface receptor-binding peptide is a vascular endothelial growth factor receptor (VEGFR)-binding peptide comprising an amino acid sequence at least 90% identical to the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2;
ii. a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide comprises 2 to 10 repeats of a histone H2A comprising SEQ ID NO: 248 or SEQ ID NO: 5; and
iii. an endosomolytic peptide, wherein the endosomolytic peptide is GALA comprising and has an amino acid at least 90% identical to the amino acid sequence set forth in SEQ ID NO: 6.
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