US 11,702,392 B2
Pyrimidinone derivatives as SHP2 antagonists
Catherine Jorand-Lebrun, Billerica, MA (US); Roch Boivin, Billerica, MA (US); Theresa Johnson, Billerica, MA (US); Yanping Wang, Billerica, MA (US); Yufang Xiao, Billerica, MA (US); Xiaoling Chen, Billerica, MA (US); Nina Linde, Darmstadt (DE); Doreen Musch, Darmstadt (DE); and Deepak Kumar, Billerica, MA (US)
Assigned to Merck Patent GmbH, Darmstadt (DE)
Filed by MERCK PATENT GMBH, Darmstadt (DE)
Filed on Feb. 22, 2021, as Appl. No. 17/181,614.
Application 17/181,614 is a continuation of application No. 16/843,735, filed on Apr. 8, 2020, granted, now 11,001,561.
Claims priority of provisional application 62/879,816, filed on Jul. 29, 2019.
Claims priority of application No. 19167897 (EP), filed on Apr. 8, 2019.
Prior Publication US 2021/0179565 A1, Jun. 17, 2021
Int. Cl. C07D 239/36 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 471/10 (2006.01); C07D 487/10 (2006.01); C07D 491/052 (2006.01); C07D 491/107 (2006.01); C07D 491/20 (2006.01); A61P 35/00 (2006.01)
CPC C07D 239/36 (2013.01) [A61P 35/00 (2018.01); C07D 239/42 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 491/052 (2013.01); C07D 491/107 (2013.01); C07D 491/20 (2013.01)] 6 Claims
 
1. The compound

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.