US 11,701,651 B2
Microfluidic device capable of removing microbubbles in channel by using porous thin film, sample injection device for preventing inflow of bubbles, and method for bonding panel of microfluidic element by using mold-releasing film
Ki-Ho Han, Busan (KR); and Hyung-Seok Cho, Busan (KR)
Assigned to INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Gimhae-si (KR)
Appl. No. 16/647,157
Filed by INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Gimhae-si (KR)
PCT Filed Oct. 31, 2018, PCT No. PCT/KR2018/013096
§ 371(c)(1), (2) Date Mar. 13, 2020,
PCT Pub. No. WO2019/107763, PCT Pub. Date Jun. 6, 2019.
Claims priority of application No. 10-2017-0160376 (KR), filed on Nov. 28, 2017; application No. 10-2017-0171352 (KR), filed on Dec. 13, 2017; and application No. 10-2017-0172265 (KR), filed on Dec. 14, 2017.
Prior Publication US 2020/0269237 A1, Aug. 27, 2020
Int. Cl. B01L 3/00 (2006.01); G01N 1/40 (2006.01)
CPC B01L 3/502707 (2013.01) [B01L 3/502753 (2013.01); B01L 2200/0684 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0887 (2013.01); G01N 2001/4016 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A sample injection device for preventing inflow of bubbles, the device comprising:
a sample inlet into which a sample is injected;
an upper panel formed with a microfluidic channel including a sample injection channel connecting a main channel to the sample inlet;
a bubble inflow-preventing means formed in a portion of the microfluidic channel to be capable of holding bubbles included in the fluid;
a porous thin film attached to a bottom surface of the microfluidic channel to remove bubbles included in the fluid passing through the microfluidic channel;
a lower panel contacting the upper panel and a bottom surface of the porous thin film and having a path for discharging bubbles, which pass through the porous thin film, to the outside; and
a vacuum-suctioning means for vacuum-suctioning the upper panel and the lower panel such that the microfluidic channel, to which the porous thin film is attached, is attached to the lower panel in a vacuum state, wherein the vacuum-suctioning means comprises a vacuum groove formed on a bottom surface of the upper panel, and a vacuum-suctioning hole communicating with the vacuum groove to apply a vacuum to the vacuum groove so that the microfluidic channel, to which the porous thin film is attached, is attached to the lower panel in a vacuum state,
wherein the bubble inflow-preventing means includes a pillar in the sample injection channel to hold bubbles so as to prevent the bubbles contained in the sample from entering into the main channel, and a bypass channel in front of the pillar in the sample injection channel to bypass the sample so as to introduce the sample into the main channel, and
wherein the bypass channel is located closer to the sample inlet than the pillar in the sample injection channel.