CPC A61K 47/6929 (2017.08) [A61K 39/0003 (2013.01); A61K 39/0011 (2013.01); A61K 39/02 (2013.01); A61K 39/118 (2013.01); A61K 39/385 (2013.01); A61K 47/643 (2017.08); A61K 47/646 (2017.08); A61K 47/6923 (2017.08); A61P 35/00 (2018.01); A61K 2039/55561 (2013.01); A61K 2039/572 (2013.01); A61K 2039/60 (2013.01); A61K 2039/622 (2013.01); B82Y 5/00 (2013.01)] | 6 Claims |
1. A method of treating head and neck squamous cell carcinoma (HNSCC) in a subject comprising: administering to a subject having at least one HNSCC tumor:
a) a composition comprising a nano-satellite complex, wherein said nano-satellite complex comprises:
i) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core;
ii) at least one satellite particle attached to, or absorbed to, said biocompatible coating;
iii) an antigenic component conjugated to, or absorbed to, said at least one satellite particle component, wherein said antigenic component comprises an antigenic peptide, wherein said antigenic peptide comprises at least one epitope from a viral oncoprotein; and
iv) a type I interferon agonist agent which is electrostatically attracted to, or absorbed to, said antigenic component; and
b) an immune checkpoint inhibitor.
|