CPC A61K 38/177 (2013.01) [A61K 35/17 (2013.01); C07K 16/18 (2013.01); C12N 15/86 (2013.01); C07K 2317/622 (2013.01)] | 7 Claims |
1. A nucleic acid molecule comprising: (a) a nucleotide sequence encoding a chimeric antigen receptor (CAR) comprising amino acids 23 to 665 of SEQ ID NO: 31 and (b) a nucleotide sequence encoding a protease sensitive scFv comprising, from amino to carboxy terminus, a VH domain comprising SEQ ID NO: 33 and a VL domain SEQ ID NO:34 joined by a protease-sensitive linker that is sensitive to MMP-2 or MMP-9.
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