US 11,701,232 B2
Acellular bioactive scaffold device and methods of fabrication and treatment relating thereto
Ting Guo, Cambridge, MA (US); John Patrick Fisher, Kensington, MD (US); Hannah Baker, Baltimore, MD (US); Max Jonah Lerman, Silver Spring, MD (US); and Robert Choe, Arlington, VA (US)
Assigned to University of Maryland, College Park, College Park, MD (US)
Filed by University of Maryland, College Park, College Park, MD (US)
Filed on Jan. 15, 2020, as Appl. No. 16/743,315.
Claims priority of provisional application 62/828,303, filed on Apr. 2, 2019.
Claims priority of provisional application 62/792,722, filed on Jan. 15, 2019.
Prior Publication US 2020/0222190 A1, Jul. 16, 2020
Int. Cl. A61F 2/30 (2006.01); A61L 27/18 (2006.01)
CPC A61F 2/30756 (2013.01) [A61L 27/18 (2013.01); A61F 2002/30766 (2013.01); A61F 2002/30985 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An implantable device comprising an acellular polymeric scaffold, wherein said acellular polymeric scaffold comprises PLCL-amine scaffold material that comprises a mixture of:
(A) poly(L-lactide-co-caprolactone) (PLCL); and
(B) an aggrecan—amine end capped poly(L-lactide-co-glycolic acid) (PLGA) conjugate, wherein said aggrecan is covalently bonded to said amine end capped PLGA via an amide bond.