US 11,701,134 B2
Histotripsy for thrombolysis
Adam D. Maxwell, Ann Arbor, MI (US); Zhen Xu, Ann Arbor, MI (US); Hitinder S. Gurm, Ann Arbor, MI (US); and Charles A. Cain, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Filed by The Regents of the University of Michigan, Ann Arbor, MI (US)
Filed on Jun. 10, 2022, as Appl. No. 17/838,085.
Application 17/838,085 is a continuation of application No. 16/293,394, filed on Mar. 5, 2019, granted, now 11,364,042.
Application 16/293,394 is a continuation of application No. 12/358,549, filed on Jan. 23, 2009, granted, now 10,219,815, issued on Mar. 5, 2019.
Application 12/358,549 is a continuation in part of application No. 12/121,001, filed on May 15, 2008, granted, now 8,057,408, issued on Nov. 15, 2011.
Application 12/121,001 is a continuation in part of application No. 11/523,201, filed on Sep. 19, 2006, abandoned.
Claims priority of provisional application 60/786,322, filed on Mar. 27, 2006.
Claims priority of provisional application 60/719,703, filed on Sep. 22, 2005.
Claims priority of provisional application 60/753,376, filed on Dec. 22, 2005.
Claims priority of provisional application 60/938,806, filed on May 18, 2007.
Claims priority of provisional application 61/023,554, filed on Jan. 25, 2008.
Prior Publication US 2022/0323088 A1, Oct. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 17/22 (2006.01); A61B 17/225 (2006.01); A61M 37/00 (2006.01); A61B 5/0536 (2021.01); A61B 5/055 (2006.01); A61B 8/00 (2006.01); A61B 8/08 (2006.01); A61B 17/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 17/22004 (2013.01) [A61B 17/2258 (2013.01); A61M 37/0092 (2013.01); A61B 5/055 (2013.01); A61B 5/0536 (2013.01); A61B 8/00 (2013.01); A61B 8/08 (2013.01); A61B 8/485 (2013.01); A61B 2017/00154 (2013.01); A61B 2017/00172 (2013.01); A61B 2017/00778 (2013.01); A61B 2017/22001 (2013.01); A61B 2017/22008 (2013.01); A61B 2017/22088 (2013.01); A61B 2017/22089 (2013.01); A61B 2090/378 (2016.02)] 6 Claims
OG exemplary drawing
 
1. A method for controlled mechanical fractionation of a target tissue, comprising:
outputting an ultrasound pulse sequence from a transducer array resulting in cavitation forming a bubble cloud;
detecting a location of the bubble cloud;
actuating the transducer array such that the bubble cloud is spatially positioned within the target tissue in response to the location of the bubble cloud;
monitoring backscatter from the bubble cloud with the transducer array; and
adjusting one or more parameters of the ultrasound pulse sequence based on the monitored backscatter from the bubble cloud.