US 7,563,868 B2
	NRIF3, a novel co-activator for nuclear hormone receptors
Vandana Yajnik, Brookline, Mass. (US); Herbert H. Samuels, New Rochelle, N.Y. (US); and Dangsheng Li, New York, N.Y. (US)
Assigned to New York University, New York, N.Y. (US)
Filed on May 19, 2003, as Appl. No. 10/441,967.
Application 10/441967 is a continuation of application No. 09/662052, filed on Sep. 15, 2000, granted, now 6,639,064.
Claims priority of provisional application 60/154347, filed on Sep. 17, 1999.
Prior Publication US 2008/0138796 A1, Jun. 12, 2008
Int. Cl. C07K 14/00 (2006.01); A61K 38/24 (2006.01)

U.S. Cl. 530—350  [530/399]

2 Claims

1. An isolated functional NRIF3 nuclear hormone receptor co-activator polypeptide (NRIF3 polypeptide), wherein the NRIF3 polypeptide binds in a ligand dependent manner to thyroid hormone receptor (TR) and retinoid X receptor (RXR), but does not interact with retinoic acid receptor (RAR), vitamin D receptor (VDR), progesterone receptor (PR), glucocorticoid receptor (GR), and estrogen receptor (ER) in a yeast two hybrid assay system or in vitro, or both, which polypeptide contains an LxxIL (SEQ ID NO:2) module in its C-terminal domain, and wherein the NRIF3 polypeptide exhibits at least about 85% identity to SEQ ID NO:4.