| US 7,563,811 B2 | ||
| 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof | ||
| Satoshi Nagato, Chiba (Japan); Kohshi Ueno, Ibaraki (Japan); Koki Kawano, Ibaraki (Japan); Yoshihiko Norimine, Ibaraki (Japan); Koichi Ito, Chiba (Japan); Takahisa Hanada, Ibaraki (Japan); Masataka Ueno, Ibaraki (Japan); Hiroyuki Amino, Ibaraki (Japan); Makoto Ogo, Ibaraki (Japan); Shinji Hatakeyama, Ibaraki (Japan); Yoshio Urawa, Ibaraki (Japan); Hiroyuki Naka, Ibaraki (Japan); Anthony John Groom, Wiltshire (United Kingdom); Leanne Rivers, Kent (United Kingdom); and Terence Smith, Cambridgeshire (United Kingdom) | ||
| Assigned to Eisai R&D Management Co., Ltd., Bunkyo-ku (Japan) | ||
| Filed on Jul. 06, 2005, as Appl. No. 11/174,514. | ||
| Application 11/174514 is a division of application No. 10/296719, granted, now 6,949,571, previously published as PCT/JP01/04857, filed on Jun. 08, 2001. | ||
| Claims priority of application No. 2000-175966 (JP), filed on Jun. 12, 2000; and application No. 0022483.2 (GB), filed on Sep. 13, 2000. | ||
| Prior Publication US 2005/0245581 A1, Nov. 03, 2005 | ||
| Int. Cl. C07D 401/02 (2006.01); A61K 31/44 (2006.01) | ||
| U.S. Cl. 514—336 [514/333; 514/334; 514/345; 514/352; 546/256; 546/257; 546/290] | 9 Claims |
1. A compound as represented by the following formula (I):
 one of X1, X2 and X3 indicates a single bond and the others independently indicate a single bond or an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —O—, —S—, —CO—, —SO—, —SO2—, —N(R6)—, —N(R7)—CO—, —CO—N(R8)—, —N(R9)—CH2—, —CH2—N(R10)—, —CH2—CO—, —CO—CH2—, —N(R11)—S(O)m—, —S(O)n—N(R12)—, —CH2—S(O)p—, —S(O)q—CH2—, —CH2—O—, —O—CH2—, —N(R13)—CO—N(R14)— or —N(R15)—CS—N(R16)— wherein R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 independently indicate a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; and m, n, p and q are independent of each other and each independently indicates an integer of 0, 1 or 2, provided
that X1, X2 and X3 do not indicate a single bond at the same time;
A1, A2 and A3 are the same as or different from each other and each independently indicates an optionally substituted C3-8 cycloalkyl group, an optionally substituted C3-8 cycloalkenyl group, an optionally substituted 5 to 14-membered non-aromatic heterocyclic group selected from the group consisting
of pyrrolidinyl groups, piperidinyl groups, piperazinyl groups, and morpholinyl groups, an optionally substituted C6-14 aromatic hydrocarbocyclic group selected from the group consisting of phenyl groups and naphthyl groups, an optionally substituted
5 to 14-membered aromatic heterocyclic group selected from the group consisting of pyrrolyl groups, pyridyl groups, pyrimidinyl
groups, pyraziny groups, thienyl groups, thiazolyl groups, furyl groups, guinolyl groups, isoquinolyl groups, indolyl groups,
benzimidazolyl groups, benzothiazolyl groups, benzoxazolyl groups, imidazopyridyl groups, carbazolyl groups, and dioxinyl
groups, or an adamantyl group; and
R17 and R18 are the same as or different from each other and each independently indicates a hydrogen atom, a halogen atom or a C1-6 alkyl group, or a salt thereof.
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