	US 7,563,785 B2
	Quetiapine analogs and methods of use thereof
Dale Edgar, Wayland, Mass. (US); David Hangauer, East Amherst, N.Y. (US); Kazumi Shiosaki, Wellesley, Mass. (US); Michael Solomon, Concord, Mass. (US); and James White, Carlisle, Mass. (US)
Assigned to Hypnion, Inc., Indianapolis, Ind. (US)
Filed on Sep. 21, 2005, as Appl. No. 11/232,565.
Claims priority of provisional application 60/623802, filed on Oct. 29, 2004.
Prior Publication US 2006/0094705 A1, May 04, 2006
Int. Cl. A61P 25/00 (2006.01); A61K 31/554 (2006.01); C07D 281/02 (2006.01)

U.S. Cl. 514—211.13 [540/551]

34 Claims

1. A method of modulating sleep in a subject, comprising administering a therapeutically effective amount of a compound of Formula IV to a subject in need thereof:

or a pharmaceutically effective salt thereof, wherein:

t is 1 or 2;

R₂, R₃, R₆, and R₇are, independently, selected from H, F, Cl, Br, CF₃, OH, CH₃, OCH₃, CH₂OCH₃, and CH₂OCH₂CH₃;

R₉and R₁₀are, independently, H, CH₃, CH₂CH₃, or

R₉and R₁₀, together with the carbon to which they are attached, are connected to form a three-membered spirocyclopropyl ring;

Z is selected from CO₂H and

provided that when Z is COOH and R₆is H, F, Cl, or Br, then R₂, R₃, R₇, R₉, and R₁₀are not each hydrogen.