| US 7,563,771 B2 | ||
| Synthetic single domain polypeptides mimicking apolipoprotein E | ||
| Gattadahalli M. Anantharamiah, Birmingham, Ala. (US); David W. Garber, Birmingham, Ala. (US); and Geeta Datta, Pelham, Ala. (US) | ||
| Assigned to UAB Research Foundation, Birmingham, Ala. (US) | ||
| Filed on Nov. 13, 2003, as Appl. No. 10/712,447. | ||
| Claims priority of provisional application 60/425821, filed on Nov. 13, 2002. | ||
| Prior Publication US 2004/0186057 A1, Sep. 23, 2004 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 38/10 (2006.01); C07K 7/08 (2006.01) | ||
| U.S. Cl. 514—14 [512/13; 530/300] | 8 Claims |
| 1. A synthetic apolipoprotein-E mimicking polypeptide comprising the amino acid sequence
X-Y-Arg-Arg-Y-Y-X-X-Y-Y-Arg-Y-Y-Arg (SEQ ID NO: 210)
wherein X is glycine, threonine, serine or alanine,
wherein Y is selected from the group consisting of phenylalanine, tyrosine, leucine, isoleucine, valine, and tryptophan,
wherein the polypeptide comprises an acetyl group at the N-terminus and an amide group at the C-terminus,
wherein the polypeptide is capable of forming an amphipathic α helical structure,
and wherein the polypeptide is also capable of binding lipoproteins.
|