| US 7,560,475 B2 | ||
| Phenylacetic acid derivative, process for producing the same, and use | ||
| Shinya Kusuda, Mishima-gun (Japan); Yoshisuke Nakayama, Mishima-gun (Japan); Hisao Tajima, Mishima-gun (Japan); and Takahiko Sakamoto, Sakai-gun (Japan) | ||
| Assigned to Ono Pharmaceutical Co., Ltd., Osaka (Japan) | ||
| Appl. No. 10/572,937 PCT Filed Sep. 21, 2004, PCT No. PCT/JP2004/014137 § 371(c)(1), (2), (4) Date Mar. 22, 2006, PCT Pub. No. WO2005/028453, PCT Pub. Date Mar. 31, 2005. |
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| Claims priority of application No. 2003-330616 (JP), filed on Sep. 22, 2003; and application No. 2004-231546 (JP), filed on Aug. 06, 2004. | ||
| Prior Publication US 2007/0105868 A1, May 10, 2007 | ||
| Int. Cl. A01N 31/425 (2006.01); A01N 43/50 (2006.01); A01N 43/76 (2006.01); A01N 43/78 (2006.01); A61K 31/42 (2006.01); A61K 31/415 (2006.01); C07D 233/54 (2006.01); C07D 263/30 (2006.01); C07D 277/22 (2006.01); C07D 413/00 (2006.01) | ||
| U.S. Cl. 514—365 [514/374; 514/396; 548/203; 548/235; 548/341.1] | 8 Claims |
1. A compound represented by formula (I)
 wherein R1 and R2 each independently represents a hydrogen atom, C1-8 alkyl, a halogen atom, C1-4 alkoxy, nitro, trihalomethyl, trihalomethoxy,
trihalomethylthio, cyano, C1-4 alkylthio or NR7R8, in which R7 and R8 each independently represents a hydrogen atom or C1-4 alkyl;
R3 represents C1-8 alkyl which may be substituted with a 1-3 halogen atom(s) or phenyl;
R4 represents a hydrogen atom or C1-8 alkyl;
R5 and R6 each independently represents a hydrogen atom or C1-4 alkyl, or R5 and R6 may be together with their neighboring carbon atom to form a carbocyclic ring;
X represents a sulfur atom, an oxygen atom or a nitrogen atom which may have a substituent(s);
ring A represents 4-(trifluoromethyl)piperidin-1-yl or 3,4-dihydro-1H-isoquinolin-2-yl,
or a salt thereof.
|