US 7,560,104 B2
	Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation
Reiner Laus, Bellevue, Wash. (US); Itzhak Hakim, Palo Alto, Calif. (US); and Damir Vidović, Bellevue, Wash. (US)
Assigned to Dendreon Corporation, Seattle, Wash. (US)
Filed on Jun. 16, 2006, as Appl. No. 11/455,031.
Prior Publication US 2006/0292165 A1, Dec. 28, 2006
Int. Cl. C12N 5/00 (2006.01); C12N 5/06 (2006.01); A61K 39/00 (2006.01)

U.S. Cl. 424—93.7  [424/93.71; 435/325]

5 Claims

1. A composition, comprising an antigen presenting cell (APC), stimulated by exposure “in vitro” to a modified antigen having an added peptidic sequence consisting of SEQ ID NO:2, wherein said stimulated APC is effective to activate T-cells to produce a cytotoxic cellular immune response against said antigen, at a T-cell activation level that is higher than that produced by such APC stimulated by the antigen alone.