US 7,560,023 B2
Method of modifying surface of material
Kazuyuki Miyazawa, Yokohama (Japan); Taketoshi Kanda, Yokohama (Japan); Yousuke Toujo, Yokohama (Japan); Aya Ohkubo, Yokohama (Japan); Osamu Shirota, Yokohama (Japan); Kenichi Sakuma, Yokohama (Japan); and Masayoshi Wada, Yokohama (Japan)
Assigned to Shiseido Company, Ltd., Tokyo (Japan)
Appl. No. 10/536,066
PCT Filed Nov. 20, 2003, PCT No. PCT/JP03/14783
§ 371(c)(1), (2), (4) Date May 24, 2005,
PCT Pub. No. WO2004/048492, PCT Pub. Date Jun. 10, 2004.
Claims priority of application No. 2002-340320 (JP), filed on Nov. 25, 2002; application No. 2002-340321 (JP), filed on Nov. 25, 2002; application No. 2003-052305 (JP), filed on Feb. 28, 2003; application No. 2003-133418 (JP), filed on May 12, 2003; and application No. 2003-169123 (JP), filed on Jun. 13, 2003.
Prior Publication US 2006/0060533 A1, Mar. 23, 2006
Int. Cl. B01D 15/08 (2006.01)
U.S. Cl. 210—198.2  [210/502.1; 210/635; 210/656] 1 Claim
OG exemplary drawing
 
1. A chromatography packing comprising:
a silica gel carrier comprised of porous spherical particles having an average particle size of 1-200 micrometers and an average pore size of 1-2000 angstroms, said carrier having a carrier surface having phosphorylcholine groups, represented by the following formula (3-1):

OG Complex Work Unit Drawing
wherein amino groups are directly introduced to the carrier surface, and then an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is reacted with said amino groups, so as to directly chemically bond the phosphorylcholine groups to the carrier surface.