US 7,557,258 B2
	Endotoxin-nonresponsive model animal
Shizuo Akira, Osaka (Japan); and Masahiro Yamamoto, Osaka (Japan)
Assigned to Japan Science and Technology Agency, Kawaguchi-Shi, Saitama (Japan)
Appl. No. 10/573,212 PCT Filed Sep. 29, 2004, PCT No. PCT/JP2004/014220 § 371(c)(1), (2), (4) Date Sep. 21, 2006, PCT Pub. No. WO2005/030269, PCT Pub. Date Apr. 07, 2005.
Claims priority of application No. 2003-338013 (JP), filed on Sep. 29, 2003.
Prior Publication US 2007/0143869 A1, Jun. 21, 2007
Int. Cl. A01K 67/027 (2006.01); G01N 33/00 (2006.01); C12N 5/06 (2006.01); C12N 5/10 (2006.01)

U.S. Cl. 800—18  [800/3; 435/354]

5 Claims

1. A transgenic homozygous TRAM-knock out mouse non-responsive to endotoxin wherein a part or a whole of TRIF-related adaptor molecule (TRAM) genes on its chromosome is deleted, a function of expressing TRAM which is expressed in a wild-type is lacked, and responsiveness to a ligand recognized by TLR4 is specifically impaired.