| US 7,557,127 B2 | ||
| HDAC inhibitor | ||
| Naoki Ishibashi, Tokyo (Japan); Yuki Sawada, Tokyo (Japan); Yasuharu Urano, Tokyo (Japan); Shigeki Satoh, Tokyo (Japan); Yoshikazu Inoue, Tokyo (Japan); Yoshiteru Eikyu, Tokyo (Japan); Koichiro Mukoyoshi, Tokyo (Japan); Kazunori Kamijo, Tokyo (Japan); Fumiyuki Shirai, Tokyo (Japan); and Hisashi Takasugi, Osaka (Japan) | ||
| Assigned to Astellas Pharma Inc., Tokyo (Japan) | ||
| Filed on Nov. 04, 2008, as Appl. No. 12/264,363. | ||
| Application 12/264363 is a division of application No. 11/199453, filed on Aug. 09, 2005, granted, now 7,465,731. | ||
| Claims priority of application No. 2004904487 (AU), filed on Aug. 09, 2004; and application No. 2004907228 (AU), filed on Dec. 20, 2004. | ||
| Prior Publication US 2009/0054464 A1, Feb. 26, 2009 | ||
| Int. Cl. C07D 401/12 (2006.01); C07D 403/12 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/501 (2006.01) | ||
| U.S. Cl. 514—318 [546/193; 546/279.1; 514/343] | 21 Claims |
1. A compound having the formula (I):
 R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl,
cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)
alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted
with one or more substituents selected from the group consisting of lower alkyl, halogen, lower alkoxy, amino, hydroxy, cyano,
aryl, aryloxy, acyl, cyclo(lower)alkyl, heteroaryl, halo(lower)alkyl and halo(lower)alkoxy,
R2 is hydrogen or lower alkyl,
X is pyrrolidinylene or piperidinylene,
Y is pyridylene, which may be substituted with one or more substituents selected from the group consisting of halogen and
lower alkyl,
Z is lower alkenylene, which may be substituted with lower alkyl or halogen,
or a salt thereof.
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