| US 7,556,935 B2 | ||
| Induction of apoptosis by cellular stress | ||
| Donald W. Kufe, Wellesley, Mass. (US); Rima Kaddurah-Daouk, Belmont, Mass. (US); and Ralph R. Weichselbaum, Chicago, Ill. (US) | ||
| Assigned to Dana-Farber Cancer Institute, Inc., Boston, Mass. (US); and The University of Chicago, Chicago, Ill. (US) | ||
| Filed on Oct. 03, 2006, as Appl. No. 11/538,186. | ||
| Application 11/538186 is a division of application No. 10/125003, filed on Apr. 18, 2002, granted, now 7,118,862. | ||
| Claims priority of provisional application 60/284785, filed on Apr. 18, 2001. | ||
| Prior Publication US 2007/0105772 A1, May 10, 2007 | ||
| Int. Cl. C12Q 1/50 (2006.01) | ||
| U.S. Cl. 435—15 [435/27] | 17 Claims |
| 1. A method for identifying a modulator of catalase ubiquitination, the method comprising:
a) contacting a polypeptide to ubiquitin in the presence of a test compound, wherein the polypeptide comprises catalase or
a fragment thereof that binds to ubiquitin;
b) measuring the ubiquitination of the polypeptide in the presence of the test compound,
wherein altered ubiquitination of the polypeptide in the presence of the test compound compared to the absence of the test
compound indicates that the compound is a modulator of catalase ubiquitination.
|