US 7,556,821 B2
Apparatus and method for transdermal delivery of parathyroid hormone agents
Mahmoud Ameri, Fremont, Calif. (US); Michel J. N. Cormier, Mountain View, Calif. (US); Yuh-Fun Maa, Millbrae, Calif. (US); Marika Kamberi, San Jose, Calif. (US); and Peter Daddona, Menlo Park, Calif. (US)
Assigned to Alza Corporation, Mountain View, Calif. (US)
Filed on Mar. 18, 2005, as Appl. No. 11/84,634.
Claims priority of provisional application 60/643660, filed on Jan. 12, 2005.
Claims priority of provisional application 60/585276, filed on Jul. 01, 2004.
Claims priority of provisional application 60/571304, filed on May 13, 2004.
Prior Publication US 2005/0256045 A1, Nov. 17, 2005
Int. Cl. A61K 9/00 (2006.01); A61M 5/00 (2006.01); A61K 38/29 (2006.01); C07K 2/00 (2006.01)
U.S. Cl. 424—423  [514/2; 530/300] 2 Claims
 
1. A device for transdermally delivering a PTH-based agent to a patient, comprising:
a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating comprising a hPTH acetate, hydrochloric acid, Tween, sucrose, and EDTA.