| US 7,393,979 B2 | ||
| Process for producing optically active 1-alkyl-substituted 2,2,2-trifluoroethylamine | ||
| Akihiro Ishii, Saitama (Japan); Yokusu Kuriyama, Niiza (Japan); Manabu Yasumoto, Kamifukuoka (Japan); Masatomi Kanai, Shiki (Japan); Kenjin Inomiya, Kamifukuoka (Japan); Takashi Ootsuka, Kamifukuoka (Japan); and Koji Ueda, Kamifukuoka (Japan) | ||
| Assigned to Central Glass Company, Limited, Ube-shi (Japan) | ||
| Appl. No. 10/560,251 PCT Filed Jun. 08, 2004, PCT No. PCT/JP2004/007955 § 371(c)(1), (2), (4) Date May 16, 2006, PCT Pub. No. WO2004/110977, PCT Pub. Date Dec. 23, 2004. |
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| Claims priority of application No. 2003-166525 (JP), filed on Jun. 11, 2003. | ||
| Prior Publication US 2006/0281950 A1, Dec. 14, 2006 | ||
| Int. Cl. C07C 209/62 (2006.01); C07C 211/05 (2006.01) | ||
| U.S. Cl. 564—486 [564/392] | 12 Claims |
1. A process for producing an optically active 1-alkyl-substituted 2,2,2-trifluoroethylamine represented by the formula [3],
 R represents a lower alkyl group of a carbon number of 1 to 6, and
* represents an asymmetric carbon, or its salt by subjecting an optically active imine represented by the formula [1],
 R represents a lower alkyl group of a carbon number of 1 to 6,
Ph represents a phenyl group,
a wavy line represents E configuration or Z configuration, and
* represents an asymmetric carbon, to an asymmetric reduction under hydrogen atmosphere using a metal catalyst of Group VIII
to convert it into an optically active secondary amine represented by the formula [2],
 R represents a lower alkyl group of a carbon number of 1 to 6,
Ph represents a phenyl group, and
* represents an asymmetric carbon, and then by subjecting the secondary amine or its salt to hydrogenolysis.
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